Thanks @Fadi - do you have right click functionality, please (as far as I can see, this is only possible on a Mac with a keyboard combo, which I don't want : this seems to be my final, deal-breaking sticking point !) ?
I have not had any issues to note. I've switched to a different Mac, but no virtualization specific issues that I can speak of, everything has run pretty smoothly for me.
While I still use Parallels routinely everyday with no issues (an am happy with it), it may also be worth looking at a hosted solution such as a co-located server running NinjaTrader. In my opinion this can offer you 'Windows in a Mac' but won't affect your local PC's resources like it would Parallels. The other advantage with this would be the latency and uptime for your trading instance.
The downsides to this are the monthly expense and requiring an internet connection to connect to the hosted server. I use both Parallels and some hosted instances and find they are both more than adequate for most of my needs.
I'm getting more impressed with virtualization performance every day!
EDIT: I also forgot to mention, right mouse click works perfectly fine! I use a regular 'PC style' external mouse and the right click 'just works'. However, on a Mac you can also CTRL + CLICK to replicate a right mouse click functionality.
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If you want to go the virtualization route I would recommend getting VMware instead of Parallels. I am not sure how close they are price wise anymore. Its more stable, faster and a better product. The Parallels' innovation process was copying everything VMware had announced would be in the next release on a tighter release cycle. At least that was the case when I worked there in 08.