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Thanks, that is good to know about the flush. I have read just read that low-dose aspirin 30 minutes before can help reduce the effect as one stages up. We are probably going to try for a kid within a year so she wants to get in top shape.
Cheers,
Rory
Can you help answer these questions from other members on NexusFi?
Among the documents unsealed was a February 2015 internal email exchange at the company about how to contain costs for a research paper. The plaintiff lawyers cited it to support their claim that the EPA report is unreliable, unlike a report by an international agency that classified glyphosate as a probable carcinogen.
Monsanto Loses Bid to Keep Glyphosate Off List of Carcinogens
“A less expensive/more palatable approach” is to rely on experts only for some areas of contention, while “we ghost-write the Exposure Tox & Genetox sections,” one Monsanto employee wrote to another.
The names of outside scientists could be listed on the publication, “but we would be keeping the cost down by us doing the writing and they would just edit & sign their names so to speak,” according to the email, which goes to on say that’s how Monsanto handled the 2000 study.
The case is In re: Roundup Products Liability Litigation, MDL 2741, U.S. District Court, Northern District of California (San Francisco).
In a recent study, people with Type 2 diabetes were asked to eat about 2-ounces of walnuts everyday, that's about 370 calories. After eight weeks, their blood vessel function improved significantly.
Why is this good news? Because endothelial cells, the thin layer of cells that lines the inside of blood vessels maybe one of the first places to go bad when people with diabetes start developing vascular disease. Walnuts help in other ways too, compared to other nuts, they have higher amounts of alpha-linolenic acid which may prevent plaque formation arteries.
I'm still researching this - reducing iron build-up.
Blood letting or donating blood seems to be the easiest way - but if you suffer from hypotension (90/60) blood donating is potential dangerous and can cause a heart attack. Target serum ferritin levels= 20 and 80 ng/ml (but in Hopkins slides serum ferritin is not a good way to measure).
Read about heme-iron (such as in meat) inhibitors e.g Calcuim and do not take absorbtion enhancers e.g Vitamin C.
Also don't take iron supplements and by a multi without it
By the way another article says that iron in veg foods (non-heme) e.g 10mg in a bowl of oatmeal - can have a low absorption - eg. 2% so less dangerous than it might seem
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A. https://www.healthtap.com/user_questions/17043-do-people-with-hypotension-donate-blood
"Absolutely not.Hypotension indicates that your body has low blood pressure from a variety of different reasons such as low blood volume, infectious or cardiac issues.If you donate blood, you are further depleting you blood pressure that can lead to dangerous events like fainting, heart attacks and veen death. "
Dr. Kevin Griffiths, Internal Medicine - Nephrology & Dialysis
Reply 2. In brief: They should not. Not recommended. Dr. Rick Koch, Internal Medicine - Cardiology
B. Hypotension is defined as "low blood pressure". Blood pressure is measured as two numbers and expressed as systolic blood pressure (sbp) / diastolic blood pressure (dbp). The sbp is the pressure that is generated when the heart squeezes. Dbp occurs when the heart relaxes. 120/70 is considered normal in adults. A systolic blood pressure of less than 90 millimeters of mercury (mm Hg) or diastolic of less than 60 mm Hg is generally considered to be hypotension.[2][3] However, in practice, blood pressure is considered too low only if noticeable symptoms are present.
C. Just don’t make the mistake of going by what’s considered “normal.”2 In some labs, a level of 395 nanograms per milliliter (ng/ml) falls within the normal range, which is FAR too high for optimal health. In reality, you’re virtually guaranteed to develop disease at that level.
Ideally, your serum ferritin should be somewhere between 20 and 80 ng/ml, certainly no higher than that. As a general rule, somewhere between 40 and 60 ng/ml is the sweet spot for adult men and non-menstruating women.
Unfortunately, few besides children, premenopausal women who lose blood through monthly menstruation, and those with acute blood loss like a bleeding ulcer, have these ideal levels.
an adult male, you’ll want to donate blood two to three times a year once your levels are normal. If ferritin levels are over 200 ng/ml, a more aggressive phlebotomy schedule is recommended.
There are two forms of iron found in food: heme and non-heme. Heme iron, which is in meat, fish and poultry, is absorbed two to three times more efficiently than non-heme iron. Whole grains, legumes, fruits and vegetables all contain non-heme iron. To lower levels of iron, limit the heme-containing foods you eat. Legumes and beans make good choices for alternative sources of protein because they're high in protein and the iron they contain is not easily absorbed. Your body may only absorb as little as 2 percent of the iron in legumes, such as lentils, black beans and split peas.
Non-Heme Inhibitors
The amount of non-heme iron your body absorbs is highly sensitive to foods that enhance or block it during digestion. Two plant-based substances, phytates and polyphenols, bind with non-heme iron and block its absorption during digestion. Phytates are found in whole grains, nuts, seeds, beans, soy products and tubers such as potatoes. Eating just a small amount of phytate may reduce non-heme iron absorption by 50 percent, according to the Linus Pauling Institute. You’ll get polyphenols from tea, coffee, cocoa and green leafy vegetables.
Heme Inhibitor
Calcium is the one substance that’s able to interfere with the absorption of heme iron. It won’t have an impact in small amounts, but consuming 300 to 600 milligrams is enough to stop some heme iron from entering your system. If you drink 1 cup of low-fat milk with your meal, its 314 milligrams of calcium are just enough to have an influence.
Absorption Enhancers
Don’t eat foods that are high in vitamin C at the same time you eat foods with iron because its one of the best enhancers of iron absorption. Foods that are rich in vitamin C may double or triple the bio-availability of iron, according to the Food and Agricultural Organization of the United Nations. Eating heme sources of iron at the same time as non-heme sources also increases the amount of iron absorbed from non-heme foods.
1,Patients who have anemia (low hemoglobin) and iron overload at the same time cannot tolerate phlebotomy (blood donation). These patients need iron chelation therapy to remove the iron.
The body cannot excrete iron, except in tiny amounts-about one milligram per day, which is sloughed off in skin or perspiration. Therefore the excess iron is trapped in the tissues of vital organs, such as the anterior pituitary, heart, liver, pancreas and joints. When the iron reaches toxic levels, damage can result in diseases such as diabetes, cirrhosis, osteoarthritis, heart attack, and hormone imbalances. Hypothyroidism, hypogonadism, infertility, impotence and sterility can result from these hormone imbalances. The patient can experience symptoms of chronic fatigue, mood swings, loss of sex drive, confusion, and memory loss. If not addressed, excess iron can result in complete organ failure and death.
iron-chelating agent such as desferrioxamine
The primary role of iron-chelation therapy is to prevent premature death from heart attack due to myocardial iron overload. Statistically 50% of patients with thalassemia major die of heart attack before the age of 35, primarily due to iron-related heart failure.
Side effects of IV iron chelation:
The urine can become orange colored, which is a harmless side effect. Immediate symptoms of adverse reaction to IV iron chelation therapy might include: visual disturbances, blurred vision, rash or hives, itching, vomiting, diarrhea, stomach or leg cramps, fever, rapid heart beat, hypotension (low blood pressure), dizziness, anaphylactic shock, and pain or swelling at site of intravenous entry. Long term problems might include kidney or liver damage, loss of hearing or cataracts.
Increased transferrin saturation (>50 %) leads to deposition of iron in
nonerythroid tissues such as the heart, liver and pancreas leading to:
Congestive heart failure
Hepatic fibrosis
Diabetes mellitus and other endocrinopathies
Increased susceptibility to infection
Increased transferrin saturation leads to the accumulation of
nontransferrin-bound iron (NBTI), labile or bound to other proteins, and
free radical formation.
The generation of free hydroxyl radicals causes tissue damage
through oxidative reactions with proteins, lipids and nuclei acids.
----------------------don't eat with meat ----------
Iron Absorption Enhancers
In the 1960s the World Health Organization found that when iron supplements were given to anemic people in Africa, there was a great increase in the death rate from infectious diseases, especially malaria. Around the same time, research began to show that the regulation of iron is a central function of the immune system, and that this seems to have evolved because iron is a basic requirement for the survival and growth of cells of all types, including bacteria, parasites, and cancer. The pioneer researcher in the role of iron in immunity believed that an excess of dietary iron contributed to the development of leukemia and lymphatic cancers. Just like lead, mercury, cadmium, nickel and other heavy metals, stored iron produces destructive free radicals. The harmful effects of iron-produced free radicals are practically indistinguishable from those caused by exposure to X-rays and gamma rays; both accelerate the accumulation of age-pigment and other signs of aging. Excess iron is a crucial element in the transformation of stress into tissue damage by free radicals.
For about 50 years, it has been known that blood transfusions damage immunity, and excess iron has been suspected to be one of the causes for this. People who regularly donate blood, on the other hand, have often been found to be healthier than non-donors, and healthier than they were before they began donating.
In one of Hans Selye's pioneering studies, he found that he could experimentally produce a form of scleroderma (hardening of the skin) in animals by administering large doses of iron, followed by a minor stress. He could prevent the development of the condition by giving the animals large doses of vitamin E, suggesting that the condition was produced by iron's oxidative actions.
Excess iron's role in infectious diseases is now well established, and many recent studies show that it is involved in degenerative brain diseases, such as Parkinson's, ALS (Lou Gehrig's disease), Huntington's chorea, and Alzheimer's disease. Iron is now believed to have a role in skin aging, atherosclerosis, and cataracts of the lenses of the eyes, largely through its formation of the "age pigment."
Q: How does excess iron accelerate our aging process?
During aging, our tissues tend to store an excess of iron. There is a remarkably close association between the amount of iron stored in our tissues and the risk of death from cancer, heart disease, or from all causes. This relationship between iron and death rate exists even during childhood, but the curve is downward until the age of 12, and then it rises steadily until death. The shape of this curve, representing the iron burden, is amazingly similar to the curves representing the rate of death in general, and the rate of death from cancer. There is no other relationship in biology that I know of that has this peculiar shape, with its minimum at the age of 12, and its maximum in old age at the time of death.
One of the major lines of aging research, going back to the early part of this century, was based on the accumulation of a brown material in the tissues known as "age-pigment." The technical name for this material, "lipofuscin," means "fatty brown stuff." In the 1960s, the "free radical theory" of aging was introduced by Denham Harman, and this theory has converged with the age-pigment theory, since we now know that the age-pigment is an oxidized mass of unsaturated fat and iron, formed by uncontrolled free radicals. Until a few years ago, these ideas were accepted by only a few researchers, but now practically every doctor in the country accepts that free radicals are important in the aging process. A nutrition researcher in San Diego suspected that the life-extending effects of calorie restriction might be the result of a decreased intake of toxins. He removed the toxic heavy metals from foods, and found that the animals which ate a normal amount of food lived as long as the semi-starved animals. Recently, the iron content of food has been identified as the major life-shortening factor, rather than the calories. [Choi and Yu, Age vol. 17, page 93, 1994.]
...
Q: How does copper help us?
Copper is the crucial element for producing the color in hair and skin, for maintaining the elasticity of skin and blood vessels, for protecting against certain types of free radical, and especially for allowing us to use oxygen properly for the production of biological energy. It is also necessary for the normal functioning of certain nerve cells (substantia nigra) whose degeneration is involved in Parkinson's disease. The shape and texture of hair, as well as its color, can change in a copper deficiency. Too much iron can block our absorption of copper, and too little copper makes us store too much iron. With aging, our tissues lose copper as they store excess iron. Because of those changes, we need more vitamin E as we age.
Herbal treatment options are also effective. Dandelion, wild hyssop and milk thistle supplements help regulate the body’s systems and minimize iron storage.
Drink green tea, as it is a powerful chelator that works to remove iron from the body.
Calcium, vitamin B6, vitamin E, manganese and black tea are also effective treatment options. Additionally, individuals affected by hemochromatosis should avoid vitamin C supplements.
Zinc also has antioxidant properties, meaning it helps protect cells in the body from damage caused by free radicals. Free radicals may contribute to the aging process, as well as the development of a number of health problems, including heart disease and cancer. Antioxidants can neutralize free radicals and may reduce or even help prevent some of the damage they cause.
Your body doesn't need a large amount of zinc. The recommended daily allowance for adults is 8 - 11 mg. It’s common to have slightly low levels of zinc, but taking a multivitamin, plus eating a healthy diet, should give you all the zinc you need.
Zinc reduces the amount of copper your body absorbs, and high doses of zinc can cause a copper deficiency. For that reason, many doctors recommend that you take 2 mg of copper along with a zinc supplement.
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You should take zinc with water or juice. If zinc causes stomach upset, it can be taken with meals. Don't take zinc at the same time as iron or calcium supplements. [so zinc blocks iron absorption?? - my question]
A strong relationship exists between zinc and copper. Too much of one can cause a deficiency in the other. If you take zinc, including zinc in a multivitamin, you should also take copper.
Adult
Men 19 years and older: 11 mg (RDA)
Women 19 years and older: 8 mg (RDA)
Pregnant women 14 - 18 years: 12 mg (RDA)
Pregnant women 19 years and older: 11 mg (RDA)
Breastfeeding women 14 - 18 years: 13 mg (RDA)
Breastfeeding women 19 years and older: 12 mg (RDA)
...
Taking 100 mg of zinc daily, or taking supplemental zinc for 10 years or longer, has been linked with a doubling of the risk developing prostate cancer in men.
---------
Possible Interactions
If you are being treated with any of the following medications, you should not use zinc without first talking to your health care provider.
Amiloride (Midamor) -- Amiloride is a potassium-sparing diuretic (water pill) that may increase the levels of zinc in your blood. Do not take zinc supplements if you take amiloride.
Blood pressure medications, ACE Inhibitors -- A class of medications called ACE inhibitors, used to treat high blood pressure, may decrease the levels of zinc in your blood. ACE inhibitors include:
However, doxycycline (Vibramycin) does not seem to interact with zinc.
Cisplatin (Platinol-AQ) -- This drug, used for chemotherapy to treat some types of cancers, may cause more zinc to be lost in your urine. If you are undergoing chemotherapy, do not take zinc or any other supplement without talking to your oncologist.
Deferoxamine (Desferal) -- This medication, used to remove excess iron from the blood, also increases the amount of zinc that is lost in urine.
Immunosuppressant medications -- Since zinc may make the immune system stronger, it should not be taken with corticosteroids (such as prednisone), cyclosporine, or other medications intended to suppress the immune system.
Penicillamine -- This medication, used to treat Wilson's disease (where excess copper builds up in the brain, liver, kidney, and eyes) and rheumatoid arthritis, decreases the levels of zinc in your blood.
Thiazide diuretics (water pills) -- These medications lower the amount of zinc in your blood by increasing the amount of zinc that is passed in your urine. If you take thiazide diuretics, your doctor will monitor levels of zinc and other important minerals in your blood:
Phytic acid (IP6), derived as an extract from rice bran, is the most
potent natural iron chelator and has strong antibiotic and antioxidant
action. [Free Radical Biology Medicine, Volume 8, 1990; Journal
Biological Chemistry, August 25, 1987] IP6 has been found to have
similar | iron-chelating properties as desferrioxamine, a drug
commonly used to kill germs, tumor cells or to remove undesirable minerals from
the body. [Biochemistry Journal, September 15, 1993] IP6 rice bran
extract (2000-4000 mg) should be taken in between meals with filtered
or bottled water only (no juice).[/shadow]
Has anybody used IP6 for Iron Chelation?
Following sites indicates that it is a natural Iron Chelator
----
A quick search finds plenty of articles about inositol hexaphosphate, or IP6, and the iron chelating properties are often mentioned. It has been mentioned as a possible weapon against cancer because it inhibits iron in tumors. It has been studied and there is some evidence that it does bind iron. To what extent and whether this could be useful to thals, I don't know, but inositol hexaphosphate is a very safe supplement, even in high doses, if anyone wants to try it out. I saw it for sale online in the US at rather low prices and I cannot think of a single reason why anyone shouldn't try it and see if it has any effect in lowering iron in their bodies.
Thank you friends for a very quick reply.
I purchased Cell forte with IP6 (Jerrows Formula) from Vitamin Shoppe.
I am collecting his Serrun Ferritin report today.
For anyone with access to US mail order, Puritan.com has a sale going right now and you can get IP-6 INOSITOL HEXAPHOSPHATE Capsules at a pretty good price. https://www.puritan.com/pages/file.asp?xs=B7DB0B6671844B85B6D102CE568187FC&PID=602&CPID=&np=1
On their home page they also have a link to Resveratrol products. I'm sure the same products can be found at many online companies. Puritan does have good quality at reasonable prices.
Emerging evidence suggests that dietary rice bran may exert beneficial effects against several types of cancer, such as breast, lung, liver, and colorectal cancer. The chemopreventive potential has been related to the bioactive phytochemicals present in the bran portion of the rice such as ferulic acid, tricin, β-sitosterol, γ-oryzanol, tocotrienols/tocopherols, and phytic acid. Studies have shown that the anticancer effects of the rice bran–derived bioactive components are mediated through their ability to induce apoptosis, inhibit cell proliferation, and alter cell cycle progression in malignant cells. Rice bran bioactive components protect against tissue damage through the scavenging of free radicals and the blocking of chronic inflammatory responses. Rice bran phytochemicals have also been shown to activate anticancer immune responses as well as affecting the colonic tumor microenvironment in favor of enhanced colorectal cancer chemoprevention. This is accomplished through the modulation of gut microflora communities and the regulation of carcinogen-metabolizing enzymes. In addition, the low cost of rice production and the accessibility of rice bran make it an appealing candidate for global dietary chemoprevention. Therefore, the establishment of dietary rice bran as a practical food-derived chemopreventive agent has the potential to have a significant impact on cancer prevention for the global population.
