I've read that Matlab can be very, very slow for this type of task. I am also unsure on it's x64 capabilities, can it really handle 25GB of data being stored in memory for calculations? I know that "technically" it can, my question though is whether or not has actual experience in testing this large of a data set?
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I last used Matlab December last year. Obviously depends on what calculations you are doing with the data. There are tricks to speed it up, such as avoiding looping commands and configuring the input data in vectors.